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Science > Knockout Mice
The following information is about Knockout Mice.
Knockout Mice Defined
Mice whose genome contains a gene whose function has been disrupted, or "knocked- out". A common method of producing disabled genes using recombinant DNA technology is by inserting an antibiotic resistance gene into the normal DNA sequence of a clone of the gene being studied. This disrupts the gene's action, thereby preventing it from making an active protein product. Cells in which this transfer is successful are then injected into mouse embryos, producing chimeric mice. These mice are bred to yield a strain in which all the cells contain the knocked- out gene. Knockout mice are used as animal models for various diseases, such as cystic fibrosis, and are helping to clarify the functions of the genes studied within the fields of immunology, cancer genetics, and developmental biology.
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Off-site Knockout Mice Links, User Submitted
The following links have been collected through user bookmark submission in the Knockout Mice category. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.
Tue Oct 30
- Knockout Transgenic Mouse
- CMC Activity Center : Transgenic and Knockout Mice : Resources : Targeting for Beginners : CMC?Nature Gateway: RPCI-23 BAC library
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Thu Mar 15
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Fri Jul 7
- MPD - Welcome to the Mouse Phenome Database
- General and Tissue-Specifi c tet-Effector Mouse Lines: tetracycline mice
- Trans-NIH Mouse Initiatives
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