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Gene Therapy
Gene Therapy
Gene Therapy
Gene Therapy
Gene Therapy

The following information is about Gene Therapy.

Gene Therapy Defined

The introduction of new genes into cells for the purpose of treating disease by restoring or adding gene expression. Techniques include insertion of retroviral vectors, transfection, homologous recombination, and injection of new genes into the nuclei of single cell embryos. The entire gene therapy process may consist of multiple steps. The new genes may be introduced into proliferating cells in vivo (e.g., bone marrow) or in vitro (e.g., fibroblast cultures) and the modified cells transferred to the site where the gene expression is required. Gene therapy may be particularly useful for treating enzyme deficiency diseases, hemoglobinopathies, and leukemias and may also prove useful in restoring drug sensitivity, particularly for leukemia.

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Blood Exosomes Shown To Contain Tumor Specific Genetic Information For Brain Cancer

Published November 18, 2008, 3:08 am, Medical News Today

Tiny vesicles called exosomes released into the bloodstream from aggressive brain tumors contain genetic signatures that may help guide future diagnosis and treatment of this deadly disease. In their report in the December issue of Nature Cell Biology (DOI: 10.

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Blood exosomes shown to contain tumor-specific genetic information for brain cancer

Published November 17, 2008, 2:02 pm, News-Medical-Net

Tiny vesicles called exosomes released into the bloodstream from aggressive brain tumors contain genetic signatures that may help guide future diagnosis and treatment of this deadly disease.

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Not just a messenger boy!

Published November 17, 2008, 12:33 pm, Deccan Herald

Recent scientific discoveries have shown that RNA, once considered a mere messenger boy for DNA, actually helps to run the show. The classic protein-making genes are still there on the double helix, but RNA seems to play a powerful role in how genes function.

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InteRNA Technologies and Cenix BioScience Ink Research Agreement for miRNA Drug Discovery

Published November 17, 2008, 6:04 am, Business Wire via Yahoo! Finance

BILTHOVEN, The Netherlands & DRESDEN, Germany----InteRNA Technologies B.V. and Cenix BioScience GmbH announce signing of a Research Agreement comprising functional screens in human cell lines using InteRNA’s proprietary library of miRNAs.

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By Combining Technologies, Researchers Rapidly Hunt Down And Find New Genes That Lead To Cancer

Published November 17, 2008, 4:31 am, BioresearchOnline

Using a new approach that combines scientific technologies to hunt down genetic changes involved in cancer, researchers have discovered 13 tumor suppressor genes that, when mutated, can lead to liver cancers.

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Novel Oral Anticoagulant, ATI-5923, Promises Potential Benefits Over Leading Treatment

Published November 17, 2008, 4:10 am, Medical News Today

ARYx Therapeutics (NASDAQ:ARYX) announced today that clinical data for ATI-5923, a novel vitamin K epoxide reductase (VKOR) inhibitor in Phase 2/3 development for the treatment of patients at risk of forming dangerous blood clots, were presented this week at the American Heart Association (AHA) Scientific Sessions 2008 in New Orleans, LA.

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Vical Executive Alain Rolland Named AAPS Fellow

Published November 17, 2008, 3:30 am, PR Newswire via Yahoo! Finance

Vical Incorporated today announced that Alain P. Rolland, Pharm.D., Ph.D., the company's Senior Vice President, Product Development, was named a Fellow of the American Association of Pharmaceutical Scientists .

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Top Scoops

Published November 16, 2008, 6:09 pm, Scoop.co.nz

Looking over the seven page questionnaire that the Obama organization has for prospective appointees, several thoughts occurred:

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British Nobel laureate conducts lecture on origins of stem cells

Published November 16, 2008, 3:10 pm, Gulf Times

By Peter Townson THE third instalment of the ‘Distinguished lecture series’, was hosted at Qatar Foundation yesterday, where Sir Martin Evans gave a presentation entitled: ‘The Origins of Embryonic Stem Cells’.

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Spark, fuel, air

Published November 15, 2008, 10:04 pm, Isthmus

While the hurt is on other sectors of the economy, the biotech industry is booming, and Madison has established itself as a hub.

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Are you looking for additional Science > Gene Therapy news? Try our new "Gene Therapy News Focus" area.

Off-site Gene Therapy Links, User Submitted

The following links have been collected through user bookmark submission in the Gene Therapy category. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.

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  • HIV News: An Ineffective Vaccine, a Potential Target for Gene Therapy: Patients may ask about two widely reported findings concerning HIV. First, the disappointing news: an international, phase 2 trial in Lancet, 3000 high-risk, HIV-negative adults were randomized to receive a cell-mediated, adenovirus-bas ed vaccine or a placebo. Vaccination did not reduce HIV infection rates or, among people who became infected, plasma viral load. In fact, in some subgroups, infection rates were higher with the vaccine. Now, the encouraging news: The Wall Street Journal has described the case of an HIV-infected man who has been off treatment and free of detectable HIV for more than 600 days ? ever since he had a bone marrow transplant for leukemia. The bone marrow donor was homozygous for a genetic mutation (CCR5 delta 32) that made him virtually immune to HIV. Writing in HIV and ID Observations, a Journal Watch blog, Paul Sax concludes: "If ever there were a plausible target for gene therapy, the CCR5 delta 32 mutation seems like a great place to start."

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