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The following information is about Animal Model.

Animal Model Defined

A laboratory animal useful for medical research because it has specific characteristics that resemble a human disease or disorder. Scientists can create animal models, usually laboratory mice, by transferring new genes into them.

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Off-site Animal Model Links, User Submitted

The following links have been collected through user bookmark submission in the Animal Model category. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.

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  • WARNING - Parkinson's, Epidemiologica l and animal model studies, Mitochondrial dysfunction - Emory University, Atlanta, Georgia, Parkinson's Institute, Sunnyvale, California - 2006: Parkinson' ;s disease (PD) is a progressive neurological disorder marked by nigrostriatal dopaminergic degeneration and development of cytoplasmic proteinaceous aggregates known as Lewy bodies. Although the pathogenic mechanisms responsible for PD are not completely understood, many clues have come from biochemical, epidemiologica l, and genetic studies. Mutations in certain genes found in rare, familial cases of PD, such as ?-synuclein and parkin, suggest a role for the ubiquitin-prot eosome system and aberrant protein aggregation. Biochemical analyses have implicated mitochondrial dysfunction in PD. Epidemiologica l and animal model studies point to a role for environmental toxins, some of which are mitochondrial inhibitors. Mitochondrial dysfunction, resulting from either genetic defects, environmental exposures or an interaction between the two, may cause ?-synuclein aggregation or neurodegenerat ion through oxidative stress or excitotoxicity .

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